Fig. 2
The overall picture of the ‘difficulties faced by patients with rare diseases’. *There are financial burdens, including medical expenses, and restrictions on subsidies based on the severity of the diseases and household income. †In Japan, in addition to the universal health insurance system, some people take out private life insurance and medical insurance. §Inadequate rules and regulations make it difficult to decide, for example, whether or not to inform the airline about their diseases when boarding an aircraft